While previous IHI calls for proposals set out the challenges to be addressed, IHI call 12 invites applicants to identify opportunities in the IHI Strategic Research and Innovation Agenda (SRIA) and turn them into proposals for IHI projects. In addition to being aligned with the SRIA, proposals will need to adhere to the broader philosophy of IHI, meaning they will have to address an unmet public health need; require a large-scale, ambitious, cross-sector public-private partnership to succeed; and have clearly described impacts on society, the economy and science.